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Our data is consistent with known features of the cHL TME, including the diversity of immune infiltrates such as lymphocytes, DCs, macrophages, neutrophils, and natural killer cells (Figure 2A), low density of HRS cells and general abundance of T cells (Figure 2A), 64 high expression of PD-L1 on HRS cells and macrophages (Figures 2A and 2E), 27 , 63 , 65 , 66 , 67 retention of MHC Class I expression in EBV-positive HRS cells (Figure 2E), 12 , 13 and a paired increase of PD-1 and PD-L1 (Figures 2F and 3F) that support favorable patient responses to anti-PD-1 blockade

rod_length__9' 9"

Colors:Federal Blue / Shady Blue

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