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Notably, the upregulated metabolites were related primarily to glutathione metabolism, including key precursors for glutathione synthesis ( γ -glutamylcysteine and acetylcysteine), metabolites involved in glutathione catabolism and its byproducts (cysteinylglycine and Cys-Gly), and both oxidized and reduced forms of glutathione (GSSG and GSH) and glutathione disulfide
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Discussion Many medications have been associated with causing acneiform eruptions on the skin, including but not limited to steroids, immune modulators, and vitamins