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MEPSEVII® (vestronidase alfa-vjbk) dosing chart Recommended Infusion Rate Schedule by Patient Weight for Administration of MEPSEVII at Recommended Dose of 4 mg/kg MEPSEVII® (vestronidase alfa-vjbk) dosing chart Recommended Infusion Rate Schedule by Patient Weight for Administration of MEPSEVII at Recommended Dose of 4 mg/kg Calculating the Dose Weigh the patient to determine the number of vials to be diluted based on the patient’s weight and the recommended dose of 4 mg/kg Total dose (mg) = Patient’s weight (kg) x 4 mg/kg (recommended dose) Total number of vials = Total dose (mg) divided by 10 mg/vial Round to the next whole vial to determine the final total volume and number of vials needed based on the patient’s weight Volume (mL) of calculated dose = Total dose (mg) divided by the 2 mg/mL concentration Calculating the Dose Weigh the patient to determine the number of vials to be diluted based on the patient’s weight and the recommended dose of 4 mg/kg Total dose (mg) = Patient’s weight (kg) x 4 mg/kg (recommended dose) Total number of vials = Total dose (mg) divided by 10 mg/vial Round to the next whole vial to determine the final total volume and number of vials needed based on the patient’s weight Volume (mL) of calculated dose = Total dose (mg) divided by the 2 mg/mL concentration

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Your plasma carries roughly 200 ng/mL of it at age 20, and about 80 ng/mL by age 60 (PMID 26236730)