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Based on the results patients with Xx, Aa, and RR genotype predominance are more prone to melasma ( 3 Melasma pathophysiology As mentioned previously, the development of melasma can be affected and precipitated through the various factors including long-term sun-exposure and UV radiation, genetic predisposition, thyroid dysfunction, special drugs, oxidative stress, hormonal imbalance, and female gender especially the pregnant women and also those who are consuming oral contraceptives (OCPs) (Ortonne et al., 2009

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