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Additionally, LS-102 stabilizes mitochondrial membrane potential, reduces the Bax/Bcl-2 ratio, and suppresses Caspase-3 expression, thereby alleviating mitochondrial fission-mediated apoptosis ( In conclusion, AS-IV mitigates cardiac I/R injury through multiple molecular mechanisms, including anti-apoptotic, anti-inflammatory, antioxidant, and mitochondrial protective effects

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The available data come from animal models , and the human evidence base is effectively empty: the 2025 systematic review in HSS Journal on the emerging use of BPC-157 in orthopaedic sports medicine concludes that clinical evidence in humans is lacking, a position echoed in the 2026 American Journal of Sports Medicine primer on injectable peptide therapy written for orthopaedic and sports medicine physicians