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We thus tested the hypothesis that increasing NAD + levels would help restore balance and improve the health of UMNs diseased due to TDP-43 pathology

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Western Blot Analysis Cell extracts were prepared in lysis buffer containing Tris-HCl, pH 7.5, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, 2 mM PMSF and 1% Triton X-100 followed by ultrasonication method

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