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4-octyl itaconate reduces human NLRP3 inflammasome constitutive activation with the cryopyrin-associated periodic syndrome p.R262W, p.D305N and p.T350M variants

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During such biosynthesis, maturation and post translational modification processes in the ER and Golgi apparatus, the sorting machineries get involved by recruiting a number of adaptor, retrieval and coat proteins such as and soluble N-ethylmaleimide sensitive attachment protein receptor (SNARE)

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