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The evidence base is preclinical for IGF-1 LR3 specifically, with adjacent human data from native rhIGF-1 (mecasermin/Increlex)

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Based on these data, the FDA approved tesamorelin (marketed as EGRIFTA) for the reduction of excess abdominal fat in HIV‑associated lipodystrophy, not as a general weight‑loss drug for the wider population.​ Tesamorelin Risks and Considerations Like all hormone‑modulating therapies, tesamorelin carries potential risks, including fluid retention, joint pain, injection‑site reactions, and effects on glucose metabolism in susceptible patients